|Other Names||Mitogen-activated protein kinase 15, MAP kinase 15, MAPK 15, Extracellular signal-regulated kinase 7, ERK-7, Extracellular signal-regulated kinase 8, ERK-8, MAPK15, ERK7, ERK8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7554a was selected from the N-term region of human ERK8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In vitro, phosphorylates MBP.|
|Tissue Location||Widely expressed with a maximal expression in lung and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
Saelzler,M.P., J. Biol. Chem. 281 (24), 16821-16832 (2006)Iavarone,C., J. Biol. Chem. 281 (15), 10567-10576 (2006)Klevernic,I.V., Biochem. J. 394 (PT 1), 365-373 (2006)Suzuki,Y., Genome Res. 14 (9), 1711-1718 (2004)
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