|Other Names||Platelet basic protein, PBP, C-X-C motif chemokine 7, Leukocyte-derived growth factor, LDGF, Macrophage-derived growth factor, MDGF, Small-inducible cytokine B7, Connective tissue-activating peptide III, CTAP-III, LA-PF4, Low-affinity platelet factor IV, TC-2, Connective tissue-activating peptide III(1-81), CTAP-III(1-81), Beta-thromboglobulin, Beta-TG, Neutrophil-activating peptide 2(74), NAP-2(74), Neutrophil-activating peptide 2(73), NAP-2(73), Neutrophil-activating peptide 2, NAP-2, TC-1, Neutrophil-activating peptide 2(1-66), NAP-2(1-66), Neutrophil-activating peptide 2(1-63), NAP-2(1-63), PPBP, CTAP3, CXCL7, SCYB7, TGB1, THBGB1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7556a was selected from the N-term region of human PPBP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CTAP3, CXCL7, SCYB7, TGB1, THBGB1|
|Function||LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.|
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Provided below are standard protocols that you may find useful for product applications.
PPBP is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
Majumdar S.,J. Biol. Chem. 266:5785-5789(1991)Zhang C.,Blood 98:610-617(2001)Aivado,M.,Proc. Natl. Acad. Sci. U.S.A. 104 (4), 1307-1312 (2007)
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