Thrombopoietin (TPO) Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P40225 |
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Clone Names | 71213147 |
Gene ID | 7066 |
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Other Names | Thrombopoietin, C-mpl ligand, ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, THPO, MGDF |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7557c was selected from the TPO region of human Thrombopoietin (TPO). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | THPO |
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Synonyms | MGDF |
Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Megakaryocytopoiesis is the cellular development process that leads to platelet production. THPO is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. It is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.
References
Baker,J.E.,Cardiovasc. Res. 77 (1), 44-53 (2008)Steinberg,O.,J. Pediatr. Hematol. Oncol. 29 (12), 822-825 (2007)Kanayasu-Toyoda,T.,J. Biol. Chem. 282 (46), 33507-33514 (2007)
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