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BBS4 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q96RK4
Clone Names 80102140
Peptide ID 80102140
Additional Information
Gene ID 585
Other Names Bardet-Biedl syndrome 4 protein, BBS4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7562c was selected from the Center region of human BBS4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BBS4
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite Cell projection, cilium, flagellum. Note=Localizes to the pericentriolar region throughout the cell cycle Centrosomal localization requires dynein
Tissue Location Ubiquitously expressed. The highest level of expression is found in the kidney
Research Areas
Citations (0)

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BBS4 contains tetratricopeptide repeats (TPR), similar to O-linked N-acetyglucosamine transferase. Mutations in the gene encoding this protein have been observed in patients with Bardet-Biedl syndrome type 4. BBS4 may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation.


Nachury,M.V.,Cell 129 (6), 1201-1213 (2007)Ye,X.,DNA Seq. 15 (3), 213-218 (2004)Kim,J.C.,Nat. Genet. 36 (5), 462-470 (2004)

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$ 80.00
Cat# BP7562c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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