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CBR1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P16152
Clone Names 80102154
Additional Information
Gene ID 873
Other Names Carbonyl reductase [NADPH] 1, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, Prostaglandin-E(2) 9-reductase, CBR1, CBR, CRN
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7563b was selected from the C-term region of human CBR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBR1 (HGNC:1548)
Synonyms CBR, CRN, SDR21C1
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231, PubMed:1921984, PubMed:17344335, PubMed:18826943). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione- conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267).
Cellular Location Cytoplasm.
Tissue Location Expressed in kidney (at protein level).
Research Areas
Citations (0)
citation

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Background

Carbonyl reductase 1 (CBR1)is one of several monomeric,NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues.

References

Colombe,L.,Exp. Dermatol. 16 (9), 762-769 (2007)Lakhman,S.S.,Mol. Pharmacol. 72 (3), 734-743 (2007)Gonzalez-Covarrubias,V.,Drug Metab. Dispos. 35 (6), 973-980 (2007)

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$ 277.78
Cat# BP7563b
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