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HARS Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P12081
Clone Names 71228117
Additional Information
Gene ID 3035
Other Names Histidine--tRNA ligase, cytoplasmic, Histidyl-tRNA synthetase, HisRS, HARS, HRS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7567a was selected from the N-term region of human HARS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HARS1 (HGNC:4816)
Synonyms HARS, HRS
Function Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:F1Q5D5}.
Tissue Location Brain, heart, liver and kidney.
Research Areas
Citations (0)
citation

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Background

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. HARS is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. This enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The protein is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.

References

Levine,S.M., Arthritis Rheum. 56 (8), 2729-2739 (2007)Lu,Q., Proc. Natl. Acad. Sci. U.S.A. 100 (13), 7626-7631 (2003)

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$ 277.78
Cat# BP7567a
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Availability: 2 weeks
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