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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PUM2 Blocking Peptide (N-term)   

PUM2 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q8TB72
Additional Information
Gene ID 23369
Other Names Pumilio homolog 2, Pumilio-2, PUM2, KIAA0235, PUMH2
Target/Specificity The synthetic peptide sequence is selected from aa 148-162 of HUMAN PUM2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PUM2
Synonyms KIAA0235, PUMH2
Function Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, called Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). May regulate DCUN1D3 mRNA levels (PubMed:25349211). Capable of deadenylation-dependent and -independent modes of repression. May support proliferation and self-renewal of stem cells by regulating the translation of key transcripts.
Cellular Location Cytoplasm. Cytoplasmic granule. Cytoplasm, perinuclear region. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells.
Tissue Location Expressed in male germ cells of adult testis (at protein level). Highly expressed in testis and ovary Predominantly expressed in stem cells and germ cells. Expressed at lower level in brain, heart, kidney, liver, muscle, placenta, intestine and stomach Expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen Expressed in all fetal tissues tested
Research Areas
Citations (0)

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PUM2 is a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. This protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of this protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation.


Gupta,Y.K., Structure 16 (4), 549-557 (2008)
Spassov,D.S.,IUBMB Life 55 (7), 359-366 (2003)
Spassov,D.S.,Gene 299 (1-2), 195-204 (2002)

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$ 80.00
$ 99.00
Cat# BP7569b
(40 western blots)
Availability: 2 weeks
Bulk Size
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