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PUM1 Antibody (Y83) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14671
Clone Names 80130138
Peptide ID 80130138
Additional Information
Gene ID 9698
Other Names Pumilio homolog 1, HsPUM, Pumilio-1, PUM1, KIAA0099, PUMH1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7569d was selected from the Y83 region of human PUM1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PUM1
Synonyms KIAA0099, PUMH1
Function Sequence-specific RNA-binding protein that negatively regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Capable of deadenylation-dependent and -independent modes of repression. May be required to support proliferation and self-renewal of stem cells.
Cellular Location Cytoplasm.
Tissue Location Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested
Research Areas
Citations (0)

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PUM1 is a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. This protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of this protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation.


Gupta,Y.K., Structure 16 (4), 549-557 (2008)Spassov,D.S.,IUBMB Life 55 (7), 359-366 (2003)Spassov,D.S.,Gene 299 (1-2), 195-204 (2002)

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$ 80.00
Cat# BP7569d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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