|Other Names||Aromatase, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7571b was selected from the C-term region of human CYP19A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARO1, CYAR, CYP19|
|Function||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|
|Cellular Location||Membrane; Peripheral membrane protein.|
|Tissue Location||Brain, placenta and gonads.|
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Provided below are standard protocols that you may find useful for product applications.
CYP19A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in the gene encoding CYP19A1 can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation.
Xita,N.,Eur. J. Endocrinol. 158 (6), 861-865 (2008)Dos Santos,R.M.,(er) DNA Cell Biol. (2008) In pressNelson,D.R.,Pharmacogenetics 14 (1), 1-18 (2004)
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