|Other Names||Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP701/HSP702, HSPA1A, HSPA1, HSX70|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7574a was selected from the Y41 region of human HSPA1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
HSPA1A is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1.
Mueller, T., et al., Transplantation 78(2):292-295 (2004).Fekete, A., et al., Pediatr. Res. 54(4):452-455 (2003).Broquet, A.H., et al., J. Biol. Chem. 278(24):21601-21606 (2003).Bruce, C.R., et al., Diabetes 52(9):2338-2345 (2003).Anwar, A., et al., J. Biol. Chem. 277(16):14060-14067 (2002).
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