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SOD2 Antibody Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04179 |
|---|
| Gene ID | 6648 |
|---|---|
| Other Names | Superoxide dismutase [Mn], mitochondrial, SOD2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7579a was selected from the region of human SOD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SOD2 |
|---|---|
| Function | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
| Cellular Location | Mitochondrion matrix. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SOD2 is a member of the iron/manganese superoxide dismutase family. It is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
References
Fabre,E.E., Am. J. Clin. Nutr. 87 (5), 1504-1512 (2008)Kaewpila,S., Cancer Res. 68 (8), 2781-2788 (2008)Flekac,M., (er) BMC Med. Genet. 9, 30 (2008)
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