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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Tyrosyl tRNA synthetase (YARS) Antibody (N-term) Blocking peptide   

Tyrosyl tRNA synthetase (YARS) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P54577
Clone Names 71228149
Peptide ID 71228149
Additional Information
Gene ID 8565
Other Names Tyrosine--tRNA ligase, cytoplasmic, Tyrosyl-tRNA synthetase, TyrRS, Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed, YARS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7580a was selected from the N-term region of human YARS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.


Yang,X.L., Chem. Biol. 14 (12), 1323-1333 (2007)Jordanova,A., Nat. Genet. 38 (2), 197-202 (2006)Bonnefond,L., Biochemistry 44 (12), 4805-4816 (2005)

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$ 80.00
Cat# BP7580a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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