HARS2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49590 |
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Clone Names | 80118108 |
Gene ID | 23438 |
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Other Names | Probable histidine--tRNA ligase, mitochondrial, Histidine--tRNA ligase-like, Histidyl-tRNA synthetase, HisRS, HARS2, HARSL, HARSR, HO3 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7584b was selected from the C-term region of human HARS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HARS2 |
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Synonyms | HARSL, HARSR, HO3 |
Function | Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). |
Cellular Location | Mitochondrion. |
Tissue Location | A high level expression is seen in the heart, kidney and skeletal muscle while a lower level expression is seen in the brain and liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
HARS2 is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Functioning in the synthesis of histidyl-transfer RNA, this enzyme plays an accessory role in the regulation of protein biosynthesis.
References
Freist,W., Biol. Chem. 380 (6), 623-646 (1999)O'Hanlon,T.P., Biochem. Biophys. Res. Commun. 210 (2), 556-566 (1995)Tsui,H.W.,Gene 131 (2), 201-208 (1993)
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