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APOE Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P02649
Clone Names 80118136
Peptide ID 80118136
Additional Information
Gene ID 348
Other Names Apolipoprotein E, Apo-E, APOE
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7587b was selected from the C-term region of human APOE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Cellular Location Secreted.
Tissue Location Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle
Research Areas
Citations (0)

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Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III),in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.


Wood,K.C., Appl Physiol Nutr Metab 33 (4), 761-768 (2008)Pemberton,L., (er) HIV Med. (2008) In pressSundermann,E.E., (er) Horm Behav (2008) In pressChristensen,H.,(er) BMC Geriatr 8, 14 (2008)

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$ 80.00
Cat# BP7587b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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