|Other Names||Nodal modulator 1, pM5 protein, NOMO1, PM5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7596c was selected from the Center region of human NOMO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May antagonize Nodal signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in colon tumor tissue and in adjacent normal colonic mucosa|
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Provided below are standard protocols that you may find useful for product applications.
NOMO1 was originally thought to be related to the collagenase family. The gene encoding NOMO1 is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE).
Blackshaw,S., PLoS Biol. 2 (9), E247 (2004)
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