RIMS2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UQ26 |
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Clone Names | 6012368 |
Gene ID | 9699 |
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Other Names | Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2, Rab-3-interacting protein 3, RIMS2, KIAA0751, RAB3IP3, RIM2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7597c was selected from the Center region of human RIMS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RIMS2 |
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Synonyms | KIAA0751, RAB3IP3, RIM2 |
Function | Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
Cellular Location | Cell membrane; Peripheral membrane protein. Synapse. Presynaptic cell membrane; Peripheral membrane protein |
Tissue Location | Widely expressed (PubMed:32470375). Expressed in melanocytes (PubMed:23999003). In fetal tissues, predominantly expressed in the brain (PubMed:32470375). In the retina, expressed in the outer plexiform layer (at protein level) (PubMed:32470375). In the cerebellum, expressed in Purkinje cells (at protein level) (PubMed:32470375). In the pancreas, expressed in Langerhans islets (at protein level) (PubMed:32470375). |
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Provided below are standard protocols that you may find useful for product applications.
Background
RIMS2 is a Rab effector involved in exocytosis. It may act as a scaffold protein. The mature cytomatrix at the active zone (CAZ) of the synapse is defined by a set of multidomain proteins that harbor several protein??rotein or protein??ipid interaction domains. The complete protein composition of the CAZ is not known to date, but it includes the proteins RIMs, Munc13-1, ERC/CAST, Piccolo/Aczonin and Bassoon. RIMs are presynaptic active zone proteins that regulate Ca2+ triggered release of neurotransmitters.
References
Imami K., Anal. Sci. 24:161-166(2008).Wang Y., Genomics 81:126-137(2003).
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