|Other Names||Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2, Rab-3-interacting protein 3, RIMS2, KIAA0751, RAB3IP3, RIM2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7597d was selected from the S427 region of human RIMS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0751, RAB3IP3, RIM2|
|Function||Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).|
|Cellular Location||Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein|
|Tissue Location||Expressed in melanocytes (PubMed:23999003).|
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Provided below are standard protocols that you may find useful for product applications.
RIMS2 is a Rab effector involved in exocytosis. It may act as a scaffold protein. The mature cytomatrix at the active zone (CAZ) of the synapse is defined by a set of multidomain proteins that harbor several protein??rotein or protein??ipid interaction domains. The complete protein composition of the CAZ is not known to date, but it includes the proteins RIMs, Munc13-1, ERC/CAST, Piccolo/Aczonin and Bassoon. RIMs are presynaptic active zone proteins that regulate Ca2+ triggered release of neurotransmitters.
Imami K., Anal. Sci. 24:161-166(2008).Wang Y., Genomics 81:126-137(2003).
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