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PIR Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O00625 |
|---|---|
| Clone Names | 80917138 |
| Gene ID | 8544 |
|---|---|
| Other Names | Pirin, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7619b was selected from the C-term region of human PIR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PIR |
|---|---|
| Function | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). |
| Cellular Location | Nucleus. Cytoplasm Note=Predominantly localized in dot-like subnuclear structures Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. |
| Tissue Location | Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PIR is a member of the cupin superfamily. The protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication.
References
Zeng,Q., Li,X. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 8), 1496-1498 (2003)Pang,H., Bartlam,M. J. Biol. Chem. 279 (2), 1491-1498 (2004)Wendler,W.M., Kremmer,E. J. Biol. Chem. 272 (13), 8482-8489 (1997)
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