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PIR Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O00625
Clone Names 80917138
Peptide ID 80917138
Additional Information
Gene ID 8544
Other Names Pirin, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7619b was selected from the C-term region of human PIR. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIR
Function Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
Cellular Location Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression
Tissue Location Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level) Expressed in all tissues, with highest level of expression in heart and liver.
Research Areas
Citations (0)

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PIR is a member of the cupin superfamily. The protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication.


Zeng,Q., Li,X. Acta Crystallogr. D Biol. Crystallogr. 59 (PT 8), 1496-1498 (2003)Pang,H., Bartlam,M. J. Biol. Chem. 279 (2), 1491-1498 (2004)Wendler,W.M., Kremmer,E. J. Biol. Chem. 272 (13), 8482-8489 (1997)

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$ 80.00
Cat# BP7619b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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