|Other Names||Phospholipid transfer protein, Lipid transfer protein II, PLTP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7620a was selected from the N-term region of human PLTP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.|
|Tissue Location||Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain|
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Provided below are standard protocols that you may find useful for product applications.
PLTP is one of at least two lipid transfer proteins found in human plasma. The protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism.
Moerland,M., Samyn,H. Arterioscler. Thromb. Vasc. Biol. 28 (7), 1277-1282 (2008)Albers,J.J., Wolfbauer,G. Biochim. Biophys. Acta 1258 (1), 27-34 (1995)
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