|Other Names||Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway, ARTS, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Cerebral protein 7, Peanut-like protein 2, SEPT4, ARTS, PNUTL2, SEP4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7621b was selected from the C-term region of human PNUTL2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARTS, PNUTL2, SEP4|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules.|
|Tissue Location||Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung Also expressed in colorectal cancers and malignant melanomas Expressed in platelets.|
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Provided below are standard protocols that you may find useful for product applications.
PNUTL2 is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein is thought to be part of a complex involved in cytokinesis.
Garcia,W., Rodrigues,N.C. Biochim. Biophys. Acta 1784 (11), 1720-1727 (2008)Garcia,W., de Araujo,A.P. Biochemistry 46 (39), 11101-11109 (2007)Paavola,P., Horelli-Kuitunen,N. Genomics 55 (1), 122-125 (1999)
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