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EphB2 Antibody (C-term) Blocking PeptideSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP7623b | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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EphB2 Antibody (C-term) Blocking Peptide - Product info | |
| Primary Accession | P29323 |
| Clone Names | 2063010 |
| Calculated MW | 117493 Da |
EphB2 Antibody (C-term) Blocking Peptide - Additional info | |
| Gene ID 2048 | |
| Target/Specificity The synthetic peptide sequence is selected from aa 1036~1051 of human EphB2. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
EphB2 Antibody (C-term) Blocking Peptide - Protein Information | |
| Name EPHB2 | |
| Synonyms DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5 | |
| Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor | |
| Cellular Location Cell membrane; Single-pass type I membrane protein. Cell projection, axon (By similarity). Cell projection, dendrite (By similarity) | |
| Tissue Location Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain | |
EphB2 Antibody (C-term) Blocking Peptide - Related products
AM7623a: EPHB2 Antibody (Ascites)
AP7623a: EphB2 Antibody (N-term)
AP7623b: EphB2 Antibody (C-term)
RI11804: EPHB2 predesign siRNA
LY11906a: EPHB2 Over-expression Lysate
BP7623a: EphB2 Antibody (N-term) Blocking Peptide
BP7623b: EphB2 Antibody (C-term) Blocking Peptide
EphB2 Antibody (C-term) Blocking Peptide - Research Areas
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BACKGROUND
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ligand-activated form of EphB2, which belongs to the Tyr family of protein kinases, interacts with multiple proteins, including GTPase-activating protein (RASGAP) through its SH2 domain. It binds RASGAP through the juxtamembrane tyrosines residues, and also interacts with PRKCABP and GRIP1 This type I membrane protein is expressed in brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. It is preferentially expressed in fetal brain. This protein contains putatively 2 fibronectin type III domains and 1 sterile alpha motif (SAM) domain.
REFERENCES
Thanos, C.D., et al., Science 283(5403):833-836 (1999).Tang, X.X., et al., Oncogene 17(4):521-526 (1998).Fox, G.M., et al., Oncogene 10(5):897-905 (1995).Ikegaki, N., et al., Hum. Mol. Genet. 4(11):2033-2045 (1995).Iwase, T., et al., Biochem. Biophys. Res. Commun. 194(2):698-705 (1993).
