POLDIP2 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y2S7 |
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Clone Names | 80917150 |
Gene ID | 26073 |
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Other Names | Polymerase delta-interacting protein 2, 38 kDa DNA polymerase delta interaction protein, p38, POLDIP2, PDIP38, POLD4 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7626b was selected from the C-term region of human POLDIP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | POLDIP2 {ECO:0000303|PubMed:26984527, ECO:0000312|HGNC:HGNC:23781} |
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Function | Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). |
Cellular Location | Mitochondrion matrix. Nucleus Note=Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
POLDIP2 is a protein that interacts with the DNA polymerase delta p50 subunit. This protein also interacts with proliferating cell nuclear antigen. Some transcripts of POLDIP2 gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).
References
Bogenhagen,D.F., J. Biol. Chem. 283 (6), 3665-3675 (2008)Klaile,E., J. Biol. Chem. 282 (36), 26629-26640 (2007)Cheng,X., J. Biochem. 138 (6), 673-678 (2005)
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