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POLDIP2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y2S7 |
|---|---|
| Clone Names | 80917149 |
| Gene ID | 26073 |
|---|---|
| Other Names | Polymerase delta-interacting protein 2, 38 kDa DNA polymerase delta interaction protein, p38, POLDIP2, PDIP38, POLD4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7626c was selected from the Center region of human POLDIP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | POLDIP2 {ECO:0000303|PubMed:26984527, ECO:0000312|HGNC:HGNC:23781} |
|---|---|
| Function | Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites (PubMed:24191025). May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (PubMed:24191025, PubMed:26984527). |
| Cellular Location | Mitochondrion matrix. Nucleus Note=Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
POLDIP2 is a protein that interacts with the DNA polymerase delta p50 subunit. This protein also interacts with proliferating cell nuclear antigen. Some transcripts of POLDIP2 gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).
References
Cheng,X., Kanki,T. J. Biochem. 138 (6), 673-678 (2005)Liu,L., Rodriguez-Belmonte,E.M. J. Biol. Chem. 278 (12), 10041-10047 (2003)
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