|Other Names||Carbonic anhydrase 3, Carbonate dehydratase III, Carbonic anhydrase III, CA-III, CA3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7633a was selected from the N-term region of human CA3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Reversible hydration of carbon dioxide.|
|Tissue Location||Muscle specific.|
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Provided below are standard protocols that you may find useful for product applications.
Carbonic anhydrase III (CAIII) is a member of carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal.
Du,A.L., Autoimmunity 42 (3), 209-215 (2009)Dai,H.Y., Mol. Carcinog. 47 (12), 956-963 (2008)Gailly,P., Kidney Int. 74 (1), 52-61 (2008)
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