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> home > Products > Peptides > Biological Process > Metabolic Process > MGRN1 Antibody (N-term) Blocking Peptide
MGRN1 Antibody (N-term) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP7634a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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MGRN1 Antibody (N-term) Blocking Peptide - Product info | |
| Primary Accession | O60291 |
| Clone Names | 80917049 |
| Calculated MW | 60753 Da |
MGRN1 Antibody (N-term) Blocking Peptide - Additional info | |
| Gene ID 23295 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7634a was selected from the N-term region of human MGRN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MGRN1 Antibody (N-term) Blocking Peptide - Protein Information | |
| Name MGRN1 | |
| Synonyms KIAA0544, RNF156 | |
| Function E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination | |
| Cellular Location Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101 Isoform 2: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli Isoform 4: Cytoplasm, cytosol. Cell membrane | |
MGRN1 Antibody (N-term) Blocking Peptide - Related products
AP7634a: MGRN1 Antibody (N-term)
AP7634b: MGRN1 Antibody (C-term)
RI13299: MGRN1 predesign siRNA
BP7634a: MGRN1 Antibody (N-term) Blocking Peptide
MGRN1 Antibody (N-term) Blocking Peptide - Research Areas
PeptidesBiological ProcessMetabolic ProcessPrimary Metabolic ProcessProtein Metabolic ProcessCellular Protein Metabolic ProcessCellular Metabolic ProcessCellular ProcessMacromolecule Metabolic ProcessCellular Macromolecule Metabolic ProcessCatabolic ProcessCellular Catabolic ProcessProteolysisMacromolecule Catabolic ProcessCellular Macromolecule Catabolic ProcessProtein Catabolic ProcessCellular Protein Catabolic ProcessProteolysis Involved In Cellular Protein Catabolic ProcessMolecular FunctionCatalytic ActivityProtein BindingLigase ActivityTissueBrainLeukocyte
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.
REFERENCES
Chakrabarti,O., Cell 137 (6), 1136-1147 (2009)Kim,B.Y., Mol. Biol. Cell 18 (4), 1129-1142 (2007)
