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MGRN1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O60291
Clone Names 80917049
Peptide ID 80917049
Additional Information
Gene ID 23295
Other Names E3 ubiquitin-protein ligase MGRN1, 632-, Mahogunin RING finger protein 1, RING finger protein 156, MGRN1, KIAA0544, RNF156
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7634a was selected from the N-term region of human MGRN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MGRN1
Synonyms KIAA0544, RNF156
Function E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Cellular Location Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101 Isoform 2: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli Isoform 4: Cytoplasm, cytosol. Cell membrane
Research Areas
Citations (0)

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Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.


Chakrabarti,O., Cell 137 (6), 1136-1147 (2009)Kim,B.Y., Mol. Biol. Cell 18 (4), 1129-1142 (2007)

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$ 80.00
Cat# BP7634a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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