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MGRN1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O60291
Clone Names 80917050
Additional Information
Gene ID 23295
Other Names E3 ubiquitin-protein ligase MGRN1, 632-, Mahogunin RING finger protein 1, RING finger protein 156, MGRN1, KIAA0544, RNF156
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7634b was selected from the C-term region of human MGRN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MGRN1
Synonyms KIAA0544, RNF156
Function E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS- binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).
Cellular Location Early endosome. Note=The endosomal localization is dependent on the interaction with TSG101 [Isoform 2]: Cytoplasm, cytosol. Nucleus. Note=Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli [Isoform 4]: Cytoplasm, cytosol. Cell membrane.
Research Areas
Citations (0)
citation

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Background

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.

References

Chakrabarti,O., Cell 137 (6), 1136-1147 (2009)Kim,B.Y., Mol. Biol. Cell 18 (4), 1129-1142 (2007)

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$ 277.78
Cat# BP7634b
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Availability: 2 weeks
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