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Insulin Receptor R Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P14616
Clone Names 2053110
Peptide ID 2053110
Additional Information
Gene ID 3645
Other Names Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, INSRR, IRR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7654b was selected from the C-term region of human INSRR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IRR
Function Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein.By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).


Shier, P., et al., J. Biol. Chem. 264(25):14605-14608 (1989).Whitmore, T.E., et al., Cytogenet. Cell Genet. 87 (1-2), 93-94 (1999).Hanze, J., et al., Horm. Metab. Res. 31 (2-3), 77-79 (1999).Shier, P., et al., Cytogenet. Cell Genet. 54 (1-2), 80-81 (1990).Elmlinger, M.W., et al., Regul. Pept. 84 (1-3), 37-42 (1999).

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$ 80.00
Cat# BP7654b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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