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CMA1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P23946
Clone Names 80410117
Peptide ID 80410117
Additional Information
Gene ID 1215
Other Names Chymase, Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7655c was selected from the Center region of human CMA1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CMA1
Synonyms CYH, CYM
Function Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Cellular Location Secreted. Cytoplasmic granule. Note=Mast cell granules
Tissue Location Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions
Research Areas
Citations (0)

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CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this protein is a target for cardiovascular disease therapies.


Raymond,W.W., J. Immunol. 182 (9), 5770-5777 (2009)Chung,W.K., J. Heart Lung Transplant. 28 (4), 373-379 (2009)Hossny,E.M., J Investig Allergol Clin Immunol 18 (5), 376-381 (2008)

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$ 80.00
Cat# BP7655c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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