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CPE Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P16870
Clone Names 80410138
Peptide ID 80410138
Additional Information
Gene ID 1363
Other Names Carboxypeptidase E, CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase, CPE
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7657b was selected from the C-term region of human CPE. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPE
Function Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
Cellular Location Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
Tissue Location Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas
Research Areas
Citations (0)

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CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in CPE gene are implicated in type II diabetes.


Oiso,S., J. Neurochem. 109 (1), 158-167 (2009)Yang,L., Ann. N. Y. Acad. Sci. 1150, 263-266 (2008)Jeffrey,K.D., Proc. Natl. Acad. Sci. U.S.A. 105 (24), 8452-8457 (2008)

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$ 80.00
Cat# BP7657b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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