|Other Names||Docking protein 6, Downstream of tyrosine kinase 6, DOK6, DOK5L|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7659b was selected from the C-term region of human DOK6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- mediated neurite growth. May have a role in brain development and/or maintenance.|
|Tissue Location||Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.|
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Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK6, a member of the p62 Dok family of intracellular adaptor molecules, promotes Ret-mediated neurite growth, and may have a role in brain development and/or maintainance Dok-6 is abundantly expressed in the fetal and adult brain and cerebellum, and is co-expressed with Ret in sympathetic, sensory, and parasympathetic ganglia, and in the ureteric buds of the developing kidneys. DOK6 Interacts via its PTB domain with phosphorylated RET through an Src-dependent mechanism, indicating that DOK6 is a substrate of the Ret-Src signaling pathway.
Crowder, R.J., et al., J. Biol. Chem. 279(40):42072-42081 (2004).
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