ROR1 Antibody Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q01973 |
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Gene ID | 4919 |
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Other Names | Tyrosine-protein kinase transmembrane receptor ROR1, Neurotrophic tyrosine kinase, receptor-related 1, ROR1, NTRKR1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7671d was selected from the region of human ROR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ROR1 |
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Synonyms | NTRKR1 |
Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). |
Cellular Location | Membrane; Single- pass type I membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z139} |
Tissue Location | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm |
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Provided below are standard protocols that you may find useful for product applications.
Background
ROR1 is a receptor protein tyrosine kinase whose cellular role has not been determined. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Studies of a similar protein in mouse suggest that this protein may interact with another receptor protein tyrosine kinase and may be involved in skeletal and cardiac development.
References
Nomi, M., et al., Mol. Cell. Biol. 21(24):8329-8335 (2001).Reddy, U.R., et al., Genomics 41(2):283-285 (1997).Reddy, U.R., et al., Oncogene 13(7):1555-1559 (1996).Masiakowski, P., et al., J. Biol. Chem. 267(36):26181-26190 (1992).
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