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DOK1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q99704
Clone Names 2072403
Peptide ID 2072403
Additional Information
Gene ID 1796
Other Names Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62, DOK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7690a was selected from the N-term region of human DOK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK1
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Cellular Location Isoform 1: Cytoplasm. Nucleus.
Tissue Location Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer
Research Areas
Citations (0)

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DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.


Liang, X., et al., J. Biol. Chem. 277(16):13732-13738 (2002).Yamakawa, N., et al., EMBO J. 21(7):1684-1694 (2002).Hubert, P., et al., Eur. J. Immunogenet. 27(3):145-148 (2000).Nemorin, J.G., et al., J. Biol. Chem. 275(19):14590-14597 (2000).Nelms, K., et al., Genomics 53(2):243-245 (1998).

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$ 80.00
Cat# BP7690a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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