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FRK Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P42685
Clone Names 2123009
Additional Information
Gene ID 2444
Other Names Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7708a was selected from the N-term region of human FRK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FRK
Synonyms PTK5, RAK
Function Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery
Tissue Location Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.


Meyer, T., et al., Int. J. Cancer 104(2):139-146 (2003).Craven, R.J., et al., Cancer Res. 55(18):3969-3972 (1995).Cance, W.G., et al., Cell Growth Differ. 5(12):1347-1355 (1994).Cance, W.G., et al., Int. J. Cancer 54(4):571-577 (1993).Lee, J., et al., Gene 138 (1-2), 247-251 (1994).

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$ 80.00
Cat# BP7708a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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