|Other Names||Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7708a was selected from the N-term region of human FRK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery|
|Tissue Location||Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.
Meyer, T., et al., Int. J. Cancer 104(2):139-146 (2003).Craven, R.J., et al., Cancer Res. 55(18):3969-3972 (1995).Cance, W.G., et al., Cell Growth Differ. 5(12):1347-1355 (1994).Cance, W.G., et al., Int. J. Cancer 54(4):571-577 (1993).Lee, J., et al., Gene 138 (1-2), 247-251 (1994).
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