|Other Names||Megakaryocyte-associated tyrosine-protein kinase, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, MATK, CTK, HYL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7714a was selected from the N-term region of human MATK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.|
|Cellular Location||Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation|
|Tissue Location||Expressed in various myeloid cell lines, detected in brain and lung|
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Provided below are standard protocols that you may find useful for product applications.
MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
Kim, S., et al., J. Biol. Chem. 277(39):36465-36470 (2002).Zagozdzon, R., et al., Int. J. Oncol. 21(6):1347-1352 (2002).Zrihan-Licht, S., et al., J. Biol. Chem. 272(3):1856-1863 (1997).Jhun, B.H., et al., J. Biol. Chem. 270(16):9661-9666 (1995).Avraham, S., et al., J. Biol. Chem. 270(4):1833-1842 (1995).
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