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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   MATK Antibody (Center) Blocking Peptide   

MATK Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P42679
Clone Names 70319184
Additional Information
Gene ID 4145
Other Names Megakaryocyte-associated tyrosine-protein kinase, CSK homologous kinase, CHK, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, MATK, CTK, HYL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7714c was selected from the Center region of human MATK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CTK, HYL
Function Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Cellular Location Cytoplasm. Membrane. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation
Tissue Location Expressed in various myeloid cell lines, detected in brain and lung
Research Areas
Citations (0)

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MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.


Kim, S., et al., J. Biol. Chem. 277(39):36465-36470 (2002).Zagozdzon, R., et al., Int. J. Oncol. 21(6):1347-1352 (2002).Zrihan-Licht, S., et al., J. Biol. Chem. 272(3):1856-1863 (1997).Jhun, B.H., et al., J. Biol. Chem. 270(16):9661-9666 (1995).Avraham, S., et al., J. Biol. Chem. 270(4):1833-1842 (1995).

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$ 80.00
Cat# BP7714c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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