|Other Names||Inactive tyrosine-protein kinase 7, Colon carcinoma kinase 4, CCK-4, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, PTK7, CCK4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7716a was selected from the N-term region of human PTK7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.|
|Cellular Location||Membrane; Single-pass type I membrane protein Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells|
|Tissue Location||Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon|
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Provided below are standard protocols that you may find useful for product applications.
PTK7 may function as a cell adhesion molecule. Although it belongs to the insulin receptor subfamily of Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, and it is weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. Expression is also detected in erythroleukemia cells.
Zhang, H., et al., Nat. Biotechnol. 21(6):660-666 (2003).Park, S.K., et al., J. Biochem. 119(2):235-239 (1996).Mossie, K., et al., Oncogene 11(10):2179-2184 (1995).
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