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YES1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P07947
Clone Names 2123001
Peptide ID 2123001
Additional Information
Gene ID 7525
Other Names Tyrosine-protein kinase Yes, Proto-oncogene c-Yes, p61-Yes, YES1, YES
Target/Specificity The synthetic peptide sequence is selected from aa 11~25 of human YES.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name YES1
Synonyms YES
Function Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
Cellular Location Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway
Tissue Location Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis
Research Areas
Citations (0)

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YES is a member of the Src family of non-receptor tyrosine kinases participating in a wide range of cellular signalling pathways.The gene that encodes YES is the cellular homolog of the Yamaguchi sarcoma virus oncogene. This gene lies in proximity to thymidylate synthase gene on chromosome 18, and a pseudogene of it has mapped to chromosome 22.


Oh, H.S., et al., J. Biol. Chem. 277(39):36489-36498 (2002).Leclerc, P., et al., Biol. Reprod. 67(1):301-307 (2002).Silverman, G.A., et al., Genomics 15(2):442-445 (1993).Brickell, P.M., Crit Rev Oncog 3(4):401-446 (1992).Sukegawa, J., et al., Mol. Cell. Biol. 7(1):41-47 (1987).

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$ 80.00
Cat# BP7725a
(40 western blots)
Availability: In Stock
Bulk Size
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