|Other Names||Leukocyte cell-derived chemotaxin-2, LECT-2, hLECT2, LECT2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7732a was selected from the N-term region of human LECT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).|
|Cellular Location||Cytoplasm. Secreted|
|Tissue Location||Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
LECT2 is a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in the LECT2 gene may be associated with rheumatoid arthritis.
Sato,Y., Transplant. Proc. 36 (8), 2359-2361 (2004)Ito,M., J. Biomol. NMR 29 (4), 543-544 (2004)Ovejero,C., Hepatology 40 (1), 167-176 (2004)
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