|Other Names||Deleted in azoospermia protein 1, DAZ1, DAZ, SPGY|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7739a was selected from the N-term region of humanZ. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis|
|Tissue Location||Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
DAZ is a member of the DAZ family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It is an RNA-binding protein that is important for spermatogenesis.
Huang,W.J., Hum. Reprod. 23 (6), 1280-1289 (2008)Lardone,M.C., Mol. Hum. Reprod. 13 (10), 705-712 (2007)
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