DAZL Antibody (Y276) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q92904 |
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Clone Names | 80130184 |
Gene ID | 1618 |
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Other Names | Deleted in azoospermia-like, DAZ homolog, DAZ-like autosomal, Deleted in azoospermia-like 1, SPGY-like-autosomal, DAZL, DAZH, DAZL1, DAZLA, SPGYLA |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7739d was selected from the Y276 region of humanZL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DAZL |
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Synonyms | DAZH, DAZL1, DAZLA, SPGYLA |
Function | RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). |
Cellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. |
Tissue Location | Testis specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The DAZ (Deleted in AZoospermia) family are potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. DAZL is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa.
References
Zerbetto,I., Fertil. Steril. 90 (6), 2264-2268 (2008)Stefanidis,K., Fertil. Steril. 90 (3), 798-804 (2008)
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