|Other Names||Cyclin-dependent kinase 5 activator 2, CDK5 activator 2, Cyclin-dependent kinase 5 regulatory subunit 2, p39, p39I, CDK5R2, NCK5AI|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7742a was selected from the p39 region of human CDK5R2(p39). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activator of CDK5/TPKII.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
|Tissue Location||Brain and neuron specific.|
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Provided below are standard protocols that you may find useful for product applications.
CDK5R2(p39) is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.
Rademakers,R., Neurobiol. Aging 26 (8), 1145-1151 (2005)Dhavan,R., J. Neurosci. 22 (18), 7879-7891 (2002)Patzke,H., J. Biol. Chem. 277 (10), 8054-8060 (2002)
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