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PRKRA Antibody (S246) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O75569
Clone Names 80130136
Peptide ID 80130136
Additional Information
Gene ID 8575
Other Names Interferon-inducible double-stranded RNA-dependent protein kinase activator A, PKR-associated protein X, PKR-associating protein X, Protein activator of the interferon-induced protein kinase, Protein kinase, interferon-inducible double-stranded RNA-dependent activator, PRKRA, PACT, RAX
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7744b was selected from the S246 region of human PRKRA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PACT, RAX
Function Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).
Cellular Location Cytoplasm, perinuclear region. Cytoplasm.
Research Areas
Citations (0)

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PRKRA appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. It activates EIF2AK2 in the absence of double-stranded RNA (dsRNA).


Seibler,P., Lancet Neurol 7 (5), 380-381 (2008)Kok,K.H., J. Biol. Chem. 282 (24), 17649-17657 (2007)Patel,R.C., EMBO J. 17 (15), 4379-4390 (1998)

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$ 80.00
Cat# BP7744b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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