|Other Names||Ras-related protein M-Ras, Ras-related protein R-Ras3, MRAS, RRAS3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7748b was selected from the C-term region of human MRAS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
|Tissue Location||Expression highly restricted to the brain and heart|
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Provided below are standard protocols that you may find useful for product applications.
Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.
Yoshikawa,Y., Mol. Biol. Cell 18 (8), 2949-2959 (2007)Mitin,N.Y., J. Biol. Chem. 279 (21), 22353-22361 (2004)Kimmelman,A.C., Mol. Cell. Biol. 22 (16), 5946-5961 (2002)
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