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MRAS Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O14807 |
|---|---|
| Clone Names | 71211137 |
| Gene ID | 22808 |
|---|---|
| Other Names | Ras-related protein M-Ras, Ras-related protein R-Ras3, MRAS, RRAS3 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7748b was selected from the C-term region of human MRAS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MRAS |
|---|---|
| Synonyms | RRAS3 |
| Function | Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway. |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
| Tissue Location | Expression highly restricted to the brain and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.
References
Yoshikawa,Y., Mol. Biol. Cell 18 (8), 2949-2959 (2007)Mitin,N.Y., J. Biol. Chem. 279 (21), 22353-22361 (2004)Kimmelman,A.C., Mol. Cell. Biol. 22 (16), 5946-5961 (2002)
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