|Other Names||Ras-related protein M-Ras, Ras-related protein R-Ras3, MRAS, RRAS3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7748c was selected from the Center region of human MRAS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side|
|Tissue Location||Expression highly restricted to the brain and heart|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.
Yoshikawa,Y., Mol. Biol. Cell 18 (8), 2949-2959 (2007)Mitin,N.Y., J. Biol. Chem. 279 (21), 22353-22361 (2004)Kimmelman,A.C., Mol. Cell. Biol. 22 (16), 5946-5961 (2002)
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