TIEG Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q13118 |
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Clone Names | 80102105 |
Gene ID | 7071 |
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Other Names | Krueppel-like factor 10, EGR-alpha, Transforming growth factor-beta-inducible early growth response protein 1, TGFB-inducible early growth response protein 1, TIEG-1, KLF10, TIEG, TIEG1 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7749a was selected from the N-term region of human TIEG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | KLF10 |
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Synonyms | TIEG, TIEG1 |
Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:O89091}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TIEG is a transcriptional repressor involved in the regulation of cell growth. TIEG binds to the consensus sequence 5'-GGTGTG-3'and inhibits cell growth.
References
Hawse,J.R., Mol. Endocrinol. 22 (7), 1579-1595 (2008)Ivanov,S.V., Biochem. Biophys. Res. Commun. 370 (4), 536-540 (2008)Jin,W., FEBS Lett. 581 (20), 3826-3832 (2007)Fueki,N., Respiration 74 (4), 454-459 (2007)
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