|Other Names||A-kinase anchor protein 7 isoforms alpha and beta, AKAP-7 isoforms alpha and beta, A-kinase anchor protein 18 kDa, AKAP 18, Protein kinase A-anchoring protein 7 isoforms alpha/beta, PRKA7 isoforms alpha/beta, AKAP7, AKAP15, AKAP18|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7750b was selected from the C-term region of human AKAP7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.|
|Cellular Location||Isoform Alpha: Lateral cell membrane; Lipid- anchor. Note=Targeted predominantly to the lateral membrane|
|Tissue Location||Expressed in brain, heart, lung, pancreas and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
AKAP7 is a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.
Brown,R.L., Biochem. Biophys. Res. Commun. 306 (2), 394-401 (2003)
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