EIF4G1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q04637 |
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Other Accession | NP_886553 |
Clone Names | 71213105 |
Gene ID | 1981 |
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Other Names | Eukaryotic translation initiation factor 4 gamma 1, eIF-4-gamma 1, eIF-4G 1, eIF-4G1, p220, EIF4G1, EIF4F, EIF4G, EIF4GI |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7755b was selected from the C-term region of human EIF4G1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EIF4G1 |
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Synonyms | EIF4F, EIF4G, EIF4GI |
Function | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:29987188). Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) (PubMed:29987188). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon (PubMed:29987188). Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning (PubMed:29987188). As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). |
Cellular Location | Cytoplasm. Nucleus. Cytoplasm, Stress granule |
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Provided below are standard protocols that you may find useful for product applications.
Background
EIF4G1 is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome.
References
Ramirez-Valle,F., J. Cell Biol. 181 (2), 293-307 (2008)Suzuki,C., Proc. Natl. Acad. Sci. U.S.A. 105 (9), 3274-3279 (2008)Peffley,D.M., Arch. Biochem. Biophys. 465 (1), 266-273 (2007)
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