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FKBP1A Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P62942
Clone Names 80513132
Peptide ID 80513132
Additional Information
Gene ID 2280
Other Names Peptidyl-prolyl cis-trans isomerase FKBP1A, PPIase FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP-12, Calstabin-1, FK506-binding protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase, FKBP1A, FKBP1, FKBP12
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7756b was selected from the C-term region of human FKBP1A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FKBP1, FKBP12
Function Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.


Gerard,M., J. Neurochem. 106 (1), 121-133 (2008)Shor,B., Cancer Res. 68 (8), 2934-2943 (2008)Jayaraman,T.,J. Biol. Chem. 267 (14), 9474-9477 (1992)

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$ 80.00
Cat# BP7756b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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