|Other Names||Neurotrophin-3, NT-3, HDNF, Nerve growth factor 2, NGF-2, Neurotrophic factor, NTF3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7763c was selected from the Center region of human NTF3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to promote the survival of visceral and proprioceptive sensory neurons.|
|Tissue Location||Brain and peripheral tissues.|
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NTF3 is a member of the neurotrophin family that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
Hossain,W.A., J. Neurosci. Res. 86 (11), 2376-2391 (2008)Mercader,J.M., Hum. Mol. Genet. 17 (9), 1234-1244 (2008)Kalcheim,C.,Proc. Natl. Acad. Sci. U.S.A. 89 (5), 1661-1665 (1992)
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