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PR48 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y5P8 |
|---|---|
| Clone Names | 71211154 |
| Gene ID | 28227 |
|---|---|
| Other Names | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta, PP2A subunit B isoform PR48, Protein phosphatase 2A 48 kDa regulatory subunit, PPP2R3B, PPP2R3L |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7772a was selected from the N-term region of human PR48. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PPP2R3B |
|---|---|
| Synonyms | PPP2R3L |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. This protein belongs to the B'' family. The B'' family has been further divided into subfamilies. This protein belongs to the beta subfamily of regulatory subunit B''.
References
Stevens,I., Eur. J. Biochem. 270 (2), 376-387 (2003)Yokoyama,N., Oncogene 20 (42), 6057-6065 (2001)Yan,Z., Mol. Cell. Biol. 20 (3), 1021-1029 (2000)
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